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Título del Articulo: Street youths are the only high-risk group for HIV in a low-prevalence South American country

Autores UMSS: Torrico F., Billot C.

Autores: Lambert M.-L., Mazina D., Marleen B., Van Stuyft P.D.

Facultad: Medicina

Centro: Instituto de Investigación Biomédicas e Investigación Social (IIBISMED)

Editorial: Lippincott, Hagerstown, MD

Fecha de Publicación: 2005     Numero de Paginas 240-242

Abstract:
Objectives: To measure HIV prevalence in various subpopulations in Bolivia.Design: In 2002 in Cochabamba, we offered voluntary counseling and testing to homeless street youths, registered and unregistered commercial sex workers, truck drivers, and prisoners. We examined surveillance data of pregnant women and blood donors.Results: Among street youths over 15, overall HIV prevalence was 3.5% (11/313), higher among those recruited in the street, lower among those recruited in centers for homeless; prevalence was 0.6% (2/334) and 0.5% (1/189) in female registered and nonregistered sex workers, respectively, and below 0.3% in all other groups. All HIV cases were attributed to sexual transmission.Conclusion: In a low-prevalence setting where intravenous drug use is uncommon, street youths are a threat for the expansion of the HIV epidemic. We argue that HIV prevention in this population requires a comprehensive approach to their health and social problems.

Para mas informacion aproximarse por : Instituto de Investigación Biomédicas e Investigación Social (IIBISMED) en la facultade de Medicina


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Título del Articulo: Cost effectiveness study of a control program of congenital Chagas disease in Bolivia [Estudio de costo/beneficio de un programa de control de Enfermedad de Chagas Congénita en Bolivia.]

Autores UMSS: Billot C., Torrico F.,

Autores: Carlier Y.

Facultad: Medicina

Centro: Instituto de Investigación Biomédicas e Investigación Social (IIBISMED)

Fecha de Publicación: 2005     Numero de Paginas 108-113

Abstract:
Cost effectiveness analysis of Chagas' vertical transmission control program in Bolivia: Today, Bolivia is the most concerned country in America by Chagas disease: Trypanosoma cruzi infection affects 20% of whole population, around 1800000 inhabitants, and mother-to-child transmission is around 5%, from 1.6 to 9.8%. Direct and indirect costs derived from disease complications and death, from birth to adulthood, add up around US$ 21 millions per year for 2,718 infected new-borns. This cost falls on individual, family and society, when the nation is struggling in a depressed economy. On the other side, an effective control program could detect and treat all cases with an investment of US$ 123 per infected new-born, or US$ 1.2 per new-born in Bolivia. Indirect benefits, apart of suffering relieve and improving of life quality, are related with Chagas vector control program, increasing the demand thanks to increasing risk awareness and also induced demand testing all pregnant women in endemic areas. So the conclusion is that such investment is profitable.

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Registro: 56    (3 / 57)


 

Título del Articulo: Deep Sequencing of the Trypanosoma cruzi GP63 Surface Proteases Reveals Diversity and Diversifying Selection among Chronic and Congenital Chagas Disease Patients

Autores UMSS: Garcia L., Torrico F.,

Autores: Llewellyn M.S., Messenger L.A., Luquetti A.O., Tavares S.B.N., Cheaib B., Derome N., Delepine M., Baulard C., Deleuze J.-F., Sauer S., Miles M.A.

Facultad: Medicina

Centro: Instituto de Investigación Biomédicas e Investigación Social (IIBISMED)

Editorial: Armando Jardim, McGill University

Fecha de Publicación: 2015     Numero de Paginas 1-23

Abstract:
Chagas disease results from infection with the diploid protozoan parasite Trypanosoma cruzi. T. cruzi is highly genetically diverse, and multiclonal infections in individual hosts are common, but little studied. In this study, we explore T. cruzi infection multiclonality in the context of age, sex and clinical profile among a cohort of chronic patients, as well as paired congenital cases from Cochabamba, Bolivia and Goias, Brazil using amplicon deep sequencing technology.

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Registro: 55    (4 / 57)


 

Título del Articulo: Tuberculosis control and the private health sector in Bolivia: A survey of pharmacies

Autores UMSS: Delgado R.

Autores: Lambert M.-L., Michaux G., Volz A., Van Der Stuyft P.

Facultad: Medicina

Centro: Instituto de Investigación Biomédicas e Investigación Social (IIBISMED)

Editorial: Union internationale contre la tuberculose et les maladies respiratoires

Fecha de Publicación: 2004     Numero de Paginas 1325-1329

Abstract:
BACKGROUND: Bolivia is a high tuberculosis (TB) incidence country with a large private for-profit health sector. TB drug sales in private pharmacies are not illegal.OBJECTIVES: To measure the availability of TB drugs in private pharmacies, study vendors' attitudes, and explore the potential for collaboration between the public health sector and pharmacies.METHODS: Simulated clients visited a random sample of 100 pharmacies in the city of Cochabamba, presenting with a prescription for four TB drugs. After the survey, contacts were made with the local Pharmacist's Association.RESULTS: Twenty-five pharmacies sold at least one drug, 23 sold rifampicin and 16 sold isoniazid. Of 99 pharmacies unable to fill the whole prescription, 59 referred the client to another pharmacy, and 22 to the public services. Pharmacists said that rifampicin was often prescribed for non-TB indications, and that TB drug sales were of minimal contribution to their income. They agreed to stop selling the drugs and to refer clients seeking them to the public sector.CONCLUSION: This study has documented a small market for TB drugs sales in private pharmacies and provided the opportunity to start collaboration with the pharmacists. Our results suggest that the private sector contributes little to managing TB in Bolivia.

Para mas informacion aproximarse por : Instituto de Investigación Biomédicas e Investigación Social (IIBISMED) en la facultade de Medicina


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Registro: 54    (5 / 57)


 

Título del Articulo: Infestation of peridomestic Attalea phalerata palms by Rhodnius stali, a vector of Trypanosoma cruzi in the Alto Beni, Bolivia

Autores UMSS: Noireau F.

Autores: Justi S.A., Cortez M.R., Monteiro F.A.

Facultad: Medicina

Centro: Instituto de Investigación Biomédicas e Investigación Social (IIBISMED)

Editorial: Blackwell, Oxford

Fecha de Publicación: 2010     Numero de Paginas 727-732

Abstract:
OBJECTIVES To determine (i) whether peridomestic Attalea phalerata palms in fragmented human-occupied areas of the Alto Beni, Bolivia, are infested by triatomines; (ii) the specific status of triatomines captured in the area; and (iii) the rate of natural Trypanosoma cruzi infection among those triatomines. METHODS One hundred and twenty-five live-bait traps were used to sample 47 A. phalerata palms in three Alto Beni localities. Active search for vectors was also performed in 10 chicken coops and three rice storage units. Only Rhodnius specimens were found. As nymphs of closely related Rhodnius species are morphologically undistinguishable, and because of controversy in the literature regarding which Rhodnius species occur in Bolivia, collected insects were identified through molecular taxonomy. Phylogenetic analyses of DNA sequences obtained for a fragment of the mitochondrial cytochrome b gene and for the nuclear ITS-2 ribosomal region were used as molecular markers. Natural infection rates were determined using a pair of primers that PCR-amplify a 330-bp fragment of the parasite's kDNA. RESULTS Twelve nymphs were captured in five A. phalerata palms (from two of the three localities studied), and an adult was collected from a chicken coop in Iniqua (and morphologically identified as Rhodnius stali). All nymphs (as well as the adult) were molecularly identified as R. stali based on the two molecular markers used. A single nymph was found to be infected with T. cruzi. CONCLUSIONS Attalea phalerata palms represent an important sylvatic ecotope occupied by R. stali in the Alto Beni region of Bolivia, where there are signs of T. cruzi transmission to humans, despite the preliminary indication of low level of natural infection of the vectors.

Para mas informacion aproximarse por : Instituto de Investigación Biomédicas e Investigación Social (IIBISMED) en la facultade de Medicina


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Registro: 53    (6 / 57)

 

Título del Articulo: Delays to treatment and out-of-pocket medical expenditure for tuberculosis patients, in an urban area of South America

Autores UMSS: Delgado R., Volz A.

Autores: Lambert M.-L., Michaux G., Speybroeck N., Van Der Stuyft P.

Facultad: Medicina

Centro: Instituto de Investigación Biomédicas e Investigación Social (IIBISMED)

Editorial: Maney Publishing, Leeds

Fecha de Publicación: 2005     Numero de Paginas 781-787

Abstract:
Short delays to treatment are important for the control of tuberculosis (TB). National Tuberculosis Programmes provide free diagnosis and treatment for smear-positive patients, so that the patients' out-of-pocket medical expenditure could be almost nil. The factors associated with delays in starting treatment, and the pre-treatment out-of-pocket medical expenditure for TB patients, have now been investigated in the Bolivian city of Cochabamba. Bolivia is the Latin American country with the highest incidence of TB. It is covered by a national TB programme that provides free diagnosis and free treatment for smear-positive patients. Structured interviews with 144 smear-positive patients enrolled in this programme revealed median patient, provider and total delays of 3.6, 6.2 and 12.9 weeks, respectively. The total delays were longer for the female patients than for the male, and for patients who consulted private doctors than for the other patients. When the first healthcare provider was a doctor, the median provider delay was 4.9 weeks in the public sector but 7.2 weeks in the private. The median out-of-pocket medical expenditure per patient, which was U.S.$13.2 overall, was much higher for those who consulted a private doctor than for those who did not (U.S.$21.9 v. U.S.$5.4, respectively; P<0.001). It appears that interventions targeting doctors (in both the private and public sectors) are likely to have a larger impact on the shortening of delays in TB treatment than interventions targeting patients. They could also reduce unnecessary out-of-pocket expenditure

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Título del Articulo: Behavioral plasticity of triatominae related to habitat selection in Northeast Brazil

Autores UMSS: Noireau F.

Autores: De La Laura A.L.C., Dias-Lima A., Lopes C.M., Emperaire L., Walter A., Ferreira A., Sherlock I.

Facultad: Medicina

Editorial: Entomological Society of America, Lanham, MD

Fecha de Publicación: 2008     Numero de Paginas 14-19

Abstract:
Triatoma pseudomaculata Corrêa and Espínola, 1964 and Triatoma juazeirensis (=T. brasiliensis Neiva, 1911 [part]), are sylvatic vectors of Trypanosoma cruzi (Chagas, 1909), the causative agent of Chagas disease, in northeast Brazil—especially in the caatinga region. In an area of caatinga in the State of Bahia, we compared the wild and peridomestic habitats of these two species of Triatominae to assess their behavioral plasticity in relation to habitat selection in different environments. In the sylvatic environment, the habitat of these two species is never shared. T. pseudomaculata is found in trees and bird nests, but without apparent preference for any particular tree species. In contrast, T. juazeirensis is exclusively rupicolous (found among rocks). Both species invade peridomestic structures but do not display a significant ability to colonize human dwellings. In the peridomestic area, they are highly adaptable to different habitats and can occupy substrates that they do not colonize in the sylvatic environment. This behavioral plasticity seems to be more striking in T. juazeirensis—rupicolous in sylvatic environments but colonizing wooden structures in the peridomicile in >80% of cases.

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Título del Articulo: Endemic level of congenital Trypanosoma cruzi infection in the areas of maternal residence and the development of congenital Chagas disease in Bolivia [Nivel de endemia de la infección por Trypanosoma cruzi en el lugar de residencia de la madre y desarrollo de la enfermedad de Chagas congénita en Bolivia.]

Autores UMSS: Faustino Torrico, Cristina Alonso-Vega, Eduardo Suarez, Patricia Rodríguez, Mary-Cruz Torrico

Autores: Michele Dramaix, Carine Truyens, Yves Carlier

Facultad: Medicina

Fecha de Publicación: 2005     Numero de Paginas 17-20

Abstract:
In Bolivia, the prevalence of infection by T. cruzi in women in fertile age can vary between 20 and 60%. The present study made in the Maternity Germin Urquidi of Cochabamba - Bolivia, it has demonstrated, that 19.9% of the mothers who go to this hospitable center to be taken care of in the childbirth, they are carrying of the infection and that 4,6% of them, they are going to transmit, by transplacentaria route, the infection to its babies. Of the 71 children born with congenital Chagas, only 47,8 % present/display some type of alteration or of development(Apgar to 1 minute low, BPN, prematuridad, pathological dismadurez) or signs (SDR, hepatomegalia, esplenomegalia, neurological signs, cardiomegalia, anasarca, petequias). When investigating the effect of the differences in the vectorial density (low, medium and high) of the zone of maternal residence, on the transmission of the infection of the mother infected to the fetus, we concluded that the rate of transmission of the congenital infection of T. cruzi is not modified by the level of endemicidad of the zone of maternal residence. By another infected new born sides whose mothers reside in zones of high endemicidad present/display, most frequently and of significant way, Apgar to 1 minute < to 7, low weight when being born and prematuridad or an association of these alterations with respiratory syndrome of distress or anasarca, when one compares them with new born of resident mothers in the zones of loss or medium endemicidad, mortality in this group is greater. These results suggest calls to account it of the mothers, in areas of high endemicidad, she is associate with a serious increase in the risk of Disease of newborn severe and mortal congenital Chagas in.

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Título del Articulo: Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: Mosaic population structure, hybridization and a role for humans in Andean parasite dispersal

Autores UMSS: Garcia, LHuaranca, CBustamante, MTorrico, MTorrico, F

Autores: Messenger L.A., Garcia L., Vanhove M., Huaranca C., Bustamante M., Torrico M., Torrico F., Miles M.A., Llewellyn M.S.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: abril 2015     Numero de Paginas 2406 - 2422

Abstract:
An improved understanding of how a parasite species exploits its genetic repertoire to colonize novel hosts and environmental niches is crucial to establish the epidemiological risk associated with emergent pathogenic genotypes. Trypanosoma cruzi, a genetically heterogeneous, multi‐host zoonosis, provides an ideal system to examine the sylvatic diversification of parasitic protozoa. In Bolivia, T. cruzi I, the oldest and most widespread genetic lineage, is pervasive across a range of ecological clines. High‐resolution nuclear (26 loci) and mitochondrial (10 loci) genotyping of 199 contemporaneous sylvatic TcI clones was undertaken to provide insights into the biogeographical basis of T. cruzi evolution. Three distinct sylvatic parasite transmission cycles were identified: one highland population among terrestrial rodent and triatomine species, composed of genetically homogenous strains (Ar = 2.95; PA/L = 0.61; DAS = 0.151), and two highly diverse, parasite assemblages circulating among predominantly arboreal mammals and vectors in the lowlands (Ar = 3.40 and 3.93; PA/L = 1.12 and 0.60; DAS = 0.425 and 0.311, respectively). Very limited gene flow between neighbouring terrestrial highland and arboreal lowland areas (distance ~220 km; FST = 0.42 and 0.35) but strong connectivity between ecologically similar but geographically disparate terrestrial highland ecotopes (distance >465 km; FST = 0.016–0.084) strongly supports ecological host fitting as the predominant mechanism of parasite diversification. Dissimilar heterozygosity estimates (excess in highlands, deficit in lowlands) and mitochondrial introgression among lowland strains may indicate fundamental differences in mating strategies between populations. Finally, accelerated parasite dissemination between densely populated, highland areas, compared to uninhabited lowland foci, likely reflects passive, long‐range anthroponotic dispersal. The impact of humans on the risk of epizootic Chagas disease transmission in Bolivia is discussed.

Para mas informacion aproximarse por : Instituto de Investigaciones Biomédicas (IIBISMED) en la facultade de Medicina


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Registro: 49    (10 / 57)


 

Título del Articulo: Collaboration between private pharmacies and national tuberculosis programme: An intervention in Bolivia

Autores UMSS: R. Delgado

Autores: Lambert M.L., Delgado R., Michaux G., Vols A., Speybroeck N., Van Der Stuyft P.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: marzo 2005     Numero de Paginas 246 – 250

Abstract:
background Public–private partnerships are felt to be necessary for tuberculosis (TB) control insome developing countries.objectives To evaluate the potential of a collaboration between the National TB Programme (NTP)and private pharmacies in Bolivia, the country with the highest TB incidence in Latin America.methods We contacted the local Pharmacists’ Association in the city of Cochabamba, and designed atwo phase intervention. The objectives of the first phase were to decrease the availability of TB drugsin private pharmacies on a voluntary basis, and to improve referral of clients seeking TB drugs to theNTP. A survey of all pharmacies allowed for a before–after comparison with a baseline survey. Theobjectives of the second phase were to obtain referral of pharmacy clients with chronic cough for TBscreening in the NTP. This phase was started in 70 pharmacies and evaluated after 2 months using thereferral slips issued by the pharmacists.results The proportion of pharmacies selling TB drugs decreased (rifampicin: 23–11.5%; isoniazid:16–3.1%; P < 0.001) and the proportion of pharmacies referring to the NTP clients seeking TBdrugs increased (22–58%; P < 0.0001). In the second phase, 26 of 70 pharmacies (38%) referred atotal of 41 clients for screening in the NTP (i.e. an average of 0.29 clients per pharmacy and per month);11 of 41 (27%) were screened and three of 11 (27%) diagnosed with smear-positive TB.conclusion The first phase of the intervention proved effective in reducing the availability of the mainTB drugs in pharmacies, and in improving referral of clients seeking TB drugs. Key factors in thissuccess were not specific to Bolivia, and collaboration between private pharmacies and public servicesappears possible in that respect. However, collaboration with pharmacies does not seem an efficient wayto increase the number of patients screened for TB, and to shorten delays to TB diagnosis and treatment

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Registro: 47    (11 / 57)


 

Título del Articulo: Development of Peptide-Based Lineage-Specific Serology for Chronic Chagas Disease: Geographical and Clinical Distribution of Epitope Recognition

Autores UMSS: Lineth Garcia

Autores: Bhattacharyya T., Falconar A.K., Luquetti A.O., Costales J.A., Grijalva M.J., Lewis M.D., Messenger L.A., Tran T.T., Ramirez J.-D., Guhl F., Carrasco H.J., Diosque P., Garcia L., Litvinov S.V., Miles M.A.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: mayo 2014     Numero de Paginas 1 - 12

Abstract:
Background: Chagas disease, caused by infection with the protozoan Trypanosoma cruzi, remains a serious public healthissue in Latin America. Genetically diverse, the species is sub-divided into six lineages, known as TcI–TcVI, which havedisparate geographical and ecological distributions. TcII, TcV, and TcVI are associated with severe human disease in theSouthern Cone countries, whereas TcI is associated with cardiomyopathy north of the Amazon. T. cruzi persists as a chronicinfection, with cardiac and/or gastrointestinal symptoms developing years or decades after initial infection. Identifying anindividual’s history of T. cruzi lineage infection directly by genotyping of the parasite is complicated by the low parasitaemiaand sequestration in the host tissues.

Sitio web: Journals

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Registro: 46    (12 / 57)

 

Título del Articulo: Achievements and Challenges upon the Implementation of a Program for National Control of Congenital Chagas in Bolivia: Results 2004-2009

Autores UMSS: Alonso-Vega C.Faustino Torrico

Autores: Alonso-Vega C., Billot C., Torrico F.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: julio 2013     Numero de Paginas

Abstract:
Bolivia is one of the most endemic countries for Chagas disease. Data of 2005 shows that incidence is around 1.09‰ inhabitants and seroprevalence in children under 15 ranged from 10% in urban areas to 40% in rural areas. In this article, we report results obtained during the implementation of the congenital Chagas program, one of the biggest casuistry in congenital Chagas disease, led by National Program of Chagas and Belgian cooperation from 2004 to 2009. The program strategy was based on serological results during pregnancy and on the follow up of children born from positive mothers until one year old; if positive, treatment was done with Benznidazole, 10 mg/Kg/day/30 days with one post treatment control 6 months later. Throughout the length of the program, a total of 318,479 pregnant women were screened and 23.31% were detected positive. 42,538 children born from positive mothers were analyzed at birth by micromethod, of which 1.43% read positive. 10,120 children returned for their second micromethod control of which 2.29% read positive, 7,650 children returned for the serological control, of which 3.32% turned out positive. From the 1,093 positive children, 70% completed the 30 day-treatment and 122 returned for post treatment control with 96% showing a negative result. It has been seen that maternal-fetal transmission rates vary between 2% and 4%, with an average of 2.6% (about half of previously reported studies that reached 5%). In this work, we show that it is possible to implement, with limited resources, a National Congenital Chagas Program and to integrate it into the Bolivian health system. Keys of success are population awareness, health personnel motivation, and political commitment at all levels.

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Registro: 45    (13 / 57)


 

Título del Articulo: Geographic distribution of human Blastocystis subtypes in South America

Autores UMSS: Garcia L

Autores: Ramírez J.D., Sánchez A., Hernández C., Flórez C., Bernal M.C., Giraldo J.C., Reyes P., López M.C., García L., Cooper P.J., Vicuña Y., Mongi F., Casero R.D.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: julio 2016     Numero de Paginas 32 - 35

Para mas informacion aproximarse por : Instituto de Investigaciones Biomédicas (IIBISMED) en la facultade de Medicina


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Registro: 44    (14 / 57)

 

Título del Articulo: Phylogenetic analysis of Bolivian bat trypanosomes of the subgenus schizotrypanum based on cytochrome b sequence and minicircle analyses

Autores UMSS: Garcia LTorrico M.C.Torrico F.

Autores: García L., Ortiz S., Osorio G., Torrico M.C., Torrico F., Solari A.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: May 9, 2012     Numero de Paginas

Abstract:
The aim of this study was to establish the phylogenetic relationships of trypanosomes present in blood samples of Bolivian Carollia bats. Eighteen cloned stocks were isolated from 115 bats belonging to Carollia perspicillata (Phyllostomidae) from three Amazonian areas of the Chapare Province of Bolivia and studied by xenodiagnosis using the vectors Rhodnius robustus and Triatoma infestans (Trypanosoma cruzi marenkellei) or haemoculture (Trypanosoma dionisii). The PCR DNA amplified was analyzed by nucleotide sequences of maxicircles encoding cytochrome b and by means of the molecular size of hyper variable regions of minicircles. Ten samples were classified as Trypanosoma cruzi marinkellei and 8 samples as Trypanosoma dionisii. The two species have a different molecular size profile with respect to the amplified regions of minicircles and also with respect to Trypanosoma cruzi and Trypanosoma rangeli used for comparative purpose. We conclude the presence of two species of bat trypanosomes in these samples, which can clearly be identified by the methods used in this study. The presence of these trypanosomes in Amazonian bats is discussed.

Sitio web: Journals

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Registro: 43    (15 / 57)

 

Título del Articulo: Short report: Amniotic fluid is not useful for diagnosis of congenital Trypanosoma cruzi infection

Autores UMSS: Alonso-Vega, C.Torrico F.Solano M.Torrico M.C.Parrado R.

Autores: Virreira M., Martinez S., Alonso-Vega C., Torrico F., Solano M., Torrico M.C., Parrado R., Truyens C., Carlier Y., Svoboda M.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: 2006     Numero de Paginas 1082 – 1084

Abstract:
Although Trypanosoma cruzi can be transmitted transplacentally and induce congenital infection, no data are available about the presence of this parasite in human amniotic fluid. We examined 8, 19, and 4 amniotic fluid samples (collected at delivery or by aspiration of gastric content of neonates) from control uninfected mothers (M−B−), infected mothers delivering uninfected newborns (M B−), and mothers of confirmed congenital cases (M B ), respectively. Polymerase chain reaction (PCR), using nuclear and kinetoplastic DNA primers (Tcz1-Tcz2 and 121–122), were negative for all control M−B− samples, but positive for 5 of 19 M B− and 2 of 4 M B samples. To determine the number of parasites in the positive samples, real-time PCR using S35/S36 kinetoplastic DNA was performed. Only one M B sample presented a high parasitic DNA amount, whereas the other six PCR-positive samples displayed traces of T. cruzi DNA. In conclusion, the release of parasites in amniotic fluid is probably a rare event that cannot be helpful for the routine diagnosis of congenital Chagas disease.

Sitio web: ajtmh

Para mas informacion aproximarse por : Instituto de Investigaciones Biomédicas (IIBISMED) en la facultade de Medicina


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Registro: 42    (16 / 57)


 

Título del Articulo: Trypanosoma cruzi: Typing of genotype (sub)lineages in megacolon samples from bolivian patients

Autores UMSS: Geovanka SerranoLuis Maldonado

Autores: Virreira M., Serrano G., Maldonado L., Svoboda M.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: diciember 2006     Numero de Paginas 252 - 255

Abstract:
Visceral dystrophy, a clinical complication of Chagas’ disease, is more frequent in southern cone countries in South America, where Trypanosoma cruzi II (TcII) lineage predominates in human infection. As this major TcII lineage is not homogeneous population and its (sub)lineages are not geographically distributed evenly, therefore, we investigated the possible relationship between parasite (sub)lineages in megacolon patients. We typified the T. cruzi lineages and (sub)lineages in megacolon samples from 18 patients using kDNA probes specific of lineage TcI, TcIIb, TcIId and TcIIe. The majority of the samples (16/18) were (sub)lineage TcIId positive. However, two samples were positive for (sub)lineage TcIIb. Two synthetic probes discriminated variants of lineage TcIId. Proportion of TcIId variants encountered were 6/16, 6/16 and 4/16, similar to the distribution of Chagasic populations in Bolivia. Our data suggest that there is no preferential tropism of one particular lineage or variant of T. cruzi II in megacolon pathology.

Sitio web: sciencedirect

Para mas informacion aproximarse por : Instituto de Investigaciones Biomédicas (IIBISMED) en la facultade de Medicina


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Registro: 41    (17 / 57)


 

Título del Articulo: Evolutionary relationships based on genetic and phenetic characters between Triatoma maculata, Triatoma pseudomaculata and morphologically related species (Reduviidae: Triatominae)

Autores UMSS: F. Noireau

Autores: dos Santos S.M., Lopes C.M., Dujardin J.P., Panzera F., Pérez R., Carbajal de la Fuente A.L., Pacheco R.S., Noireau F.

Facultad: Medicina

Fecha de Publicación: July 2007     Numero de Paginas 469 -4 75

Abstract:
The maculata group currently comprises two species of Triatominae, Triatoma maculata and Triatoma pseudomaculata, which share morphologic and chromatic characteristics. In order to clarify the systematic status of these two vectors of Trypanosoma cruzi and to infer their evolutionary relationships, we performed an enzymatic, morphometric and cytogenetic comparison of them, also taking into account two sister species not included in the group (T. arthurneivai and T. wygodzinskyi). According to our results, T. maculata and T. pseudomaculata belong to distinct evolutionary lineages. Similarly, T. arthurneivai topotypes from Minas Gerais form an independent isolated group by morphometrics. Our results also support the specific status of the Triatoma population from São Paulo State (formerly referred to T. arthurneivai), and suggest the possibility that it is T. wygodzinskyi. Finally, we suggest that only the arboricolous T. pseudomaculata from northeast Brazil and the rupicolous sister species originated from São Paulo State should be classified together in the same group.

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Registro: 40    (18 / 57)


 

Título del Articulo: Research priorities for neglected infectious diseases in Latin America and the Caribbean Region

Autores UMSS: Lineth GarciaFaustino Torrico

Autores: Dujardin J.-C., Herrera S., do Rosario V., Arevalo J., Boelaert M., Carrasco H.J., Correa-Oliveira R., Garcia L., Gotuzzo E., Gyorkos T.W., Kalergis A.M., Kouri G., Larraga V., Lutumba P., Garcia M.A.M., Manrique-Saide P.C., Modabber F., Nieto A., Pluschke G., Robello C., de Arias A.R., Rumbo M., Preciado J.I.S., Sundar S., Torres J., Torrico F., van der Stuyft P., Victoir K., Olesen O.F.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: 2010     Numero de Paginas

Abstract:
Global priorities for research in neglected infectious diseases (NIDs) can be assessed in different ways, but it is important to realize that regional priorities may significantly differ one from another. The region of Latin America and the Caribbean (LAC) is—along with Africa and Asia—more affected by NIDs than other regions of the world. Some of the Latin American NIDs are common to other continents, while others are very specific or disproportionately affect the Latin American region [1– 3] (Table 1). Because of its huge ecological diversity, ongoing environmental changes, and massive migrations, LAC is also a catalyst for the (re-)emergence and spreading of NIDs, both inside and outside the subcontinent. Following a colloquium on NIDs in LAC held in Lima, Peru, between 12 and 14 November 2009, a thematic workshop was organized with the support of the European Commission (EC). It involved 29 scientists (16 from the Americas, two from the Democratic Republic of Congo and India, respectively, and nine from Europe) working on different NIDs and representing several research areas from basic to applied. This report summarizes the consensus comments of the expert group after oral and written consultation. It is envisaged that this document should stimulate a debate within the scientific community and serve as a recommendation for future actions by international or regional funding agencies in the area of NIDs in LAC.

Para mas informacion aproximarse por : Instituto de Investigaciones Biomédicas (IIBISMED) en la facultade de Medicina


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Registro: 39    (19 / 57)


 

Título del Articulo: New insights on the spread of Triatoma infestans from Bolivia-Implications for Chagas disease emergence in the Southern Cone

Autores UMSS: F. Noireau

Autores: Cortez M.R., Monteiro F.A., Noireau F.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Abstract:
Triatoma infestans, now eliminated from most of South America by control campaigns, has been and still is the main Chagas disease vector due to its ability to colonize rural dwellings. The traditional hypothesis put forth to explain T. infestans adaptation to the synanthropic environment rests on the domestication of wild guinea pigs, one of its natural hosts, by Andean tribes about 5000 BC. Here we present two new hypotheses, based on organized human social activities. The first involves maize production, storage and distribution during the Inca period. Maize granaries could host wild rodent populations that would attract sylvatic T. infestans that were later dispersed during maize distribution. The second hypothesis is associated with the contemporary Urkupiña Virgin festival, near Cochabamba, where thousands of pilgrims gather for rituals in an area that is part of a sylvatic T. infestans focus, thus favoring the contact with the insects and leading to their passive dispersal.

Para mas informacion aproximarse por : Instituto de Investigaciones Biomédicas (IIBISMED) en la facultade de Medicina


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Registro: 38    (20 / 57)


 

Título del Articulo: New insights on the spread of Triatoma infestans from Bolivia-Implications for Chagas disease emergence in the Southern Cone

Autores UMSS: F. Noireau

Autores: Cortez M.R., Monteiro F.A.

Facultad: Medicina

Centro: Instituto de Investigaciones Biomédicas (IIBISMED)

Fecha de Publicación: 2010     Numero de Paginas 350-353

Abstract:
Triatoma infestans, now eliminated from most of South America by control campaigns, has been and still is the main Chagas disease vector due to its ability to colonize rural dwellings. The traditional hypothesis put forth to explain T. infestans adaptation to the synanthropic environment rests on the domestication of wild guinea pigs, one of its natural hosts, by Andean tribes about 5000 BC. Here we present two new hypotheses, based on organized human social activities. The first involves maize production, storage and distribution during the Inca period. Maize granaries could host wild rodent populations that would attract sylvatic T. infestans that were later dispersed during maize distribution. The second hypothesis is associated with the contemporary Urkupiña Virgin festival, near Cochabamba, where thousands of pilgrims gather for rituals in an area that is part of a sylvatic T. infestans focus, thus favoring the contact with the insects and leading to their passive dispersal.

Sitio web: sciencedirect

Para mas informacion aproximarse por : Instituto de Investigaciones Biomédicas (IIBISMED) en la facultade de Medicina




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